A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level,ChemBioChem

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A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level
ChemBioChem ( IF 2.6 ) Pub Date : 2017-08-17 08:11:38 , DOI: 10.1002/cbic.201700301
Sho Konno ₁ , Fumihiro Ishikawa _{1,

2} , Takehiro Suzuki ₃ , Naoshi Dohmae ₃ , Hideaki Kakeya ₁ , Genzoh Tanabe ₂

Affiliation

Probing cellular activity of inhibitors: Phosphopantetheinylation is an essential post-translational protein modification used in the production of many pharmaceuticals. A chemoproteomics approach to investigate 4′-phosphopantetheine transferase (PPTase) activity enables a precise interpretation of the cellular activities of Sfp-type PPTase inhibitors.

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