Influence of iron metabolism on manganese transport and toxicity,Metallomics

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Influence of iron metabolism on manganese transport and toxicity
Metallomics ( IF 2.9 ) Pub Date : 2017-05-31 00:00:00 , DOI: 10.1039/c7mt00079k
Qi Ye _{1,

2,

3,

4} , Jo Eun Park _{1,

2,

3,

4} , Kuljeet Gugnani _{1,

3,

4,

5} , Swati Betharia _{1,

3,

4,

5} , Alejandro Pino-Figueroa _{1,

3,

4,

5} , Jonghan Kim _{1,

2,

3,

4}

Affiliation

Although manganese (Mn) is critical for the proper functioning of various metabolic enzymes and cofactors, excess Mn in the brain causes neurotoxicity. While the exact transport mechanism of Mn has not been fully understood, several importers and exporters for Mn have been identified over the past decade. In addition to Mn-specific transporters, it has been demonstrated that iron transporters can mediate Mn transport in the brain and peripheral tissues. However, while the expression of iron transporters is regulated by body iron stores, whether or not disorders of iron metabolism modify Mn homeostasis has not been systematically discussed. The present review will provide an update on the role of altered iron status in the transport and toxicity of Mn.

中文翻译：

铁代谢对锰运输和毒性的影响

尽管锰对各种代谢酶和辅助因子的正常功能至关重要，但大脑中过量的锰会引起神经毒性。尽管尚未完全了解锰的确切运输机制，但在过去十年中已经确定了几个进出口商。除锰特异性转运蛋白外，已证明铁转运蛋白可介导脑和周围组织中的锰转运。然而，尽管铁转运蛋白的表达受体内铁储备的调节，但铁代谢紊乱是否会改变Mn体内稳态尚未得到系统的讨论。本综述将提供有关铁状态变化在锰的运输和毒性中作用的最新信息。

更新日期：2017-05-31

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