A simple and straightforward assembly of the yohimban skeleton was achieved by condensation of an acyclic β-keto ester with tryptamine, followed by consecutive cross metathesis and tandem cyclization reactions, leading to the formation of three new rings. The whole process was readily carried out in the one-flask providing a rapid entry to the pentacyclic scaffold of yohimbine alkaloids.

中文翻译：

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用于合成育亨班骨架的一锅法

通过无环 β-酮酯与色胺缩合，随后进行连续的交叉复分解和串联环化反应，形成三个新环，从而实现了育亨班骨架的简单直接组装。整个过程很容易在一个烧瓶中进行，提供快速进入育亨宾生物碱的五环支架。