General Principles and Strategies for Salting-Out Informed by the Hofmeister Series,Organic Process Research & Development

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General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-08-15 00:00:00 , DOI: 10.1021/acs.oprd.7b00197
Alan M. Hyde ₁ , Susan L. Zultanski ₁ , Jacob H. Waldman ₁ , Yong-Li Zhong ₁ , Michael Shevlin ₁ , Feng Peng ₁

Affiliation

Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of this technique using the Hofmeister series as a foundational basis for choosing the right salt. The power of this approach is exemplified by the aqueous workup of a highly water-soluble nucleoside in which the use of sodium sulfate allowed for high recoveries without relying on back extraction.

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