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Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-15 00:00:00 , DOI: 10.1021/acs.accounts.7b00154 Daniel A. Sheik 1 , Stephen Dewhurst 2 , Jerry Yang 1
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-15 00:00:00 , DOI: 10.1021/acs.accounts.7b00154 Daniel A. Sheik 1 , Stephen Dewhurst 2 , Jerry Yang 1
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Amyloids refer to a class of protein or peptide aggregates that are heterogeneous in size, morphology, and composition, and are implicated to play a central role in many neurodegenerative and systemic diseases. The strong correlation between biological activity and extent of aggregation of amyloidogenic proteins and peptides has led to an explosion of research efforts to target these materials with synthetic molecules or engineered antibodies to try to attenuate their function in disease pathology.
中文翻译：
天然精浆淀粉样蛋白作为HIV传播合成抑制剂发展的目标。
淀粉样蛋白是指一类蛋白质或肽聚集体，其大小，形态和组成均不相同，并且在许多神经退行性疾病和全身性疾病中起着核心作用。生物学活性与淀粉样蛋白生成的蛋白质和肽的聚集程度之间的密切相关性导致了针对合成材料或工程抗体靶向这些材料以减弱其在疾病病理中作用的研究工作的爆炸式增长。
更新日期：2017-08-15
中文翻译：
天然精浆淀粉样蛋白作为HIV传播合成抑制剂发展的目标。
淀粉样蛋白是指一类蛋白质或肽聚集体，其大小，形态和组成均不相同，并且在许多神经退行性疾病和全身性疾病中起着核心作用。生物学活性与淀粉样蛋白生成的蛋白质和肽的聚集程度之间的密切相关性导致了针对合成材料或工程抗体靶向这些材料以减弱其在疾病病理中作用的研究工作的爆炸式增长。
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