Although effector and regulatory T-cell populations can promote either neurotoxic or neuroprotective effects in the control of the brain's microenvironment, how these cells are induced during Parkinson's disease is not known.^1,2 David Sulzer and colleagues³ have reported a functional role of α-synuclein in immune tolerance. The authors posit that lymphocyte populations emerge from α-synuclein induction of autoreactive CD4+ and CD8+ T cells.

中文翻译：

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T细胞和帕金森氏病

尽管效应子和调节性T细胞群体可以在控制大脑的微环境中促进神经毒性或神经保护作用，但在帕金森氏病期间如何诱导这些细胞尚不清楚。^1,2 David Sulzer及其同事³报告了α-突触核蛋白在免疫耐受中的功能作用。作者认为，淋巴细胞群体是由α-突触核蛋白诱导的自身反应性CD4 +和CD8 + T细胞产生的。