Abstract

The Pd-catalyzed cross-coupling between N-tosylhydrazones and organic halides is a powerful method for the creation of C–C bonds. This transformation has been included recently in cascade processes in which the same catalyst promotes various independent catalytic steps, a process known as auto-tandem catalysis. This strategy proves to be very useful for the construction of relatively complex carbo- and heterocyclic structures, as well as for the generation of molecular diversity. This short review will cover the different Pd-catalyzed auto-tandem reactions­ involving N-tosylhydrazones organized by the bond-forming sequence: C–C/C–N and C–C/C–C. Some examples of related tandem reactions leading to acyclic compounds are also highlighted.

1 Introduction

2 Auto-Tandem C–C/C–N Bond-Forming Reactions

3 Auto-Tandem C–C/C–C Bond-Forming Reactions

4 Tandem Reactions for the Synthesis of Linear Molecules

5 Summary and Outlook

The Pd-catalyzed cross-coupling between N-tosylhydrazones and organic halides is a powerful method for the creation of C–C bonds. This transformation has been included recently in cascade processes in which the same catalyst promotes various independent catalytic steps, a process known as auto-tandem catalysis. This strategy proves to be very useful for the construction of relatively complex carbo- and heterocyclic structures, as well as for the generation of molecular diversity. This short review will cover the different Pd-catalyzed auto-tandem reactions­ involving N-tosylhydrazones organized by the bond-forming sequence: C–C/C–N and C–C/C–C. Some examples of related tandem reactions leading to acyclic compounds are also highlighted.

1 Introduction

2 Auto-Tandem C–C/C–N Bond-Forming Reactions

3 Auto-Tandem C–C/C–C Bond-Forming Reactions

4 Tandem Reactions for the Synthesis of Linear Molecules

5 Summary and Outlook

中文翻译：

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基于N-磺酰hydr的钯催化自动串联级联反应：杂化和碳环化过程

摘要

N-甲苯磺酰hydr与有机卤化物之间的Pd催化交叉偶联是创建C–C键的有效方法。最近，这种转化已包含在级联过程中，在该级联过程中，相同的催化剂促进了各种独立的催化步骤，该过程称为自动串联催化。事实证明，该策略对于构建相对复杂的碳和杂环结构以及生成分子多样性非常有用。这篇简短的综述将涵盖由N-甲苯磺酰hydr酮组成的不同Pd催化自动串联反应，这些反应由成键序列C–C / C–N和C–C / C–C组成。还突出了导致无环化合物的相关串联反应的一些例子。

1引言

2个自动串联的C–C / C–N键形成反应

3自动串联C–C / CC–C键形成反应

线性分子合成的4个串联反应

5总结与展望

N-甲苯磺酰hydr与有机卤化物之间的Pd催化交叉偶联是创建C–C键的有效方法。最近，这种转化已包含在级联过程中，在该级联过程中，相同的催化剂促进了各种独立的催化步骤，该过程称为自动串联催化。事实证明，该策略对于构建相对复杂的碳和杂环结构以及生成分子多样性非常有用。这篇简短的综述将涵盖由N-甲苯磺酰hydr酮组成的不同Pd催化自动串联反应，这些反应由成键序列C–C / C–N和C–C / C–C组成。还突出了导致无环化合物的相关串联反应的一些例子。

1引言

2个自动串联的C–C / C–N键形成反应

3自动串联C–C / CC–C键形成反应

线性分子合成的4个串联反应

5总结与展望