Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease.

中文翻译：

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二甲双胍对 1 型糖尿病患者的心血管和代谢影响 (REMOVAL)：一项双盲、随机、安慰剂对照试验。

二甲双胍可能会降低 1 型糖尿病患者的胰岛素需求并改善血糖，但它是否具有心血管益处尚不清楚。我们的目的是研究二甲双胍治疗（添加到滴定胰岛素治疗中）是否可以减少心血管疾病风险增加的 1 型糖尿病成人患者的动脉粥样硬化，该动脉粥样硬化是通过颈总动脉内膜中层厚度 (cIMT) 的进展来衡量的。