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Detection, risk factors, and functional consequences of cerebral microinfarcts.
The Lancet ( IF 98.4 ) Pub Date : 2017-09-01 , DOI: 10.1016/s1474-4422(17)30196-5 Susanne J van Veluw 1 , Andy Y Shih 2 , Eric E Smith 3 , Christopher Chen 4 , Julie A Schneider 5 , Joanna M Wardlaw 6 , Steven M Greenberg 7 , Geert Jan Biessels 8
The Lancet ( IF 98.4 ) Pub Date : 2017-09-01 , DOI: 10.1016/s1474-4422(17)30196-5 Susanne J van Veluw 1 , Andy Y Shih 2 , Eric E Smith 3 , Christopher Chen 4 , Julie A Schneider 5 , Joanna M Wardlaw 6 , Steven M Greenberg 7 , Geert Jan Biessels 8
Affiliation
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Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the small size of these lesions, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measurable disruption to structural brain connections, and are associated with dementia that is independent of Alzheimer's disease pathology or larger infarcts (ie, lacunar infarcts, and large cortical and non-lacunar subcortical infarcts). Substantial progress has been made with regard to understanding risk factors and functional consequences of cerebral microinfarcts, partly driven by new in-vivo detection methods and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts in human beings. Evidence from these advances suggests that cerebral microinfarcts can be manifestations of both small vessel and large vessel disease, that cerebral microinfarcts are independently associated with cognitive impairment, and that these lesions are likely to cause damage to brain structure and function that extends beyond their actual lesion boundaries. Criteria for the identification of cerebral microinfarcts with in-vivo MRI are provided to support further studies of the association between these lesions and cerebrovascular disease and dementia.
中文翻译：
脑微梗塞的检测、危险因素和功能后果。
脑微梗塞是推测为缺血性的小病变。尽管这些病变的范围很小，但受影响的个体可能会出现数百至数千个脑微梗塞，这会对大脑结构连接造成可测量的破坏，并与独立于阿尔茨海默氏病病理或较大梗塞（即腔隙性梗塞和大面积皮质和非腔隙性皮质下梗塞）。在了解脑微梗塞的危险因素和功能后果方面已经取得了实质性进展，部分原因是新的体内检测方法和密切模仿人类脑微梗塞多个方面的动物模型的开发。这些进展的证据表明，脑微梗塞可以是小血管和大血管疾病的表现，脑微梗塞与认知障碍独立相关，并且这些病变可能对大脑结构和功能造成超出其实际病变范围的损害边界。提供了体内 MRI 识别脑微梗塞的标准，以支持进一步研究这些病变与脑血管疾病和痴呆之间的关联。
更新日期：2017-08-10
中文翻译：
脑微梗塞的检测、危险因素和功能后果。
脑微梗塞是推测为缺血性的小病变。尽管这些病变的范围很小，但受影响的个体可能会出现数百至数千个脑微梗塞，这会对大脑结构连接造成可测量的破坏，并与独立于阿尔茨海默氏病病理或较大梗塞（即腔隙性梗塞和大面积皮质和非腔隙性皮质下梗塞）。在了解脑微梗塞的危险因素和功能后果方面已经取得了实质性进展，部分原因是新的体内检测方法和密切模仿人类脑微梗塞多个方面的动物模型的开发。这些进展的证据表明，脑微梗塞可以是小血管和大血管疾病的表现，脑微梗塞与认知障碍独立相关，并且这些病变可能对大脑结构和功能造成超出其实际病变范围的损害边界。提供了体内 MRI 识别脑微梗塞的标准，以支持进一步研究这些病变与脑血管疾病和痴呆之间的关联。
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