Whether elevated serum homocysteine concentrations (ie, hyperhomocysteinaemia) are a risk factor for ischaemic stroke and if normalising hyperhomocysteinaemia might reduce stroke risk are controversial issues. Hyperhomocysteinaemia can be primary (ie, hereditary) or secondary (ie, due to vitamin B12 deficiency, diabetes, etc). The effect of both primary and secondary hyperhomocysteinaemia on putative stroke risk is debated. One study¹ has shown that hyperhomocysteinaemia is an independent risk factor for ischaemic stroke, whereas other studies have reached different conclusions.

中文翻译：

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高同型半胱氨酸血症的缺血性中风的风险低

血清同型半胱氨酸浓度升高（即高同型半胱氨酸血症）是否是缺血性中风的危险因素以及正常化高同型半胱氨酸血症是否可能降低中风风险是有争议的问题。高同型半胱氨酸血症可以是原发性（即遗传性）或继发性（即由于维生素B12缺乏，糖尿病等）。对原发性和继发性高同型半胱氨酸血症对推定中风风险的影响进行了辩论。一项研究¹显示高同型半胱氨酸血症是缺血性中风的独立危险因素，而其他研究则得出了不同的结论。