Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species,Journal of Natural Products

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Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-08-10 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00331
Manuel A. Aparicio-Cuevas , Isabel Rivero-Cruz , Mariano Sánchez-Castellanos , Daniel Menéndez ₁ , Huzefa A. Raja ₂ , Pedro Joseph-Nathan ₃ , María del Carmen González , Mario Figueroa

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Two new dioxomorpholines, 1 and 2, three new derivatives, 3–5, and the known compound PF1233 B (6) were isolated from a marine-facultative Aspergillus sp. MEXU 27854. Their structures were established by 1D and 2D NMR and HRESIMS data analysis. The absolute configuration of 1 and 2 was elucidated by comparison of experimental and DFT-calculated vibrational circular dichroism spectra. Compounds 3, 5, and 6 were noncytotoxic to a panel of human cancer cell lines with different functional status for the tumor-suppressor protein p53, but were inhibitors of P-glycoprotein-reversing multidrug resistance in a doxorubicin-resistant cell line.

中文翻译：

海洋恶性曲霉物种的二氧吗啉及其衍生物

两个新dioxomorpholines，1和2，三个新的衍生物，3 - 5，和已知化合物PF1233 B（6）从一个海洋兼分离曲霉属。MEXU27854。它们的结构是通过1D和2D NMR和HRESIMS数据分析确定的。通过比较实验和DFT计算的振动圆二色性光谱，阐明了1和2的绝对构型。化合物3，5，和6 对一组具有不同抑癌蛋白p53功能状态的人类癌细胞系无细胞毒性，但在对阿霉素耐药的细胞系中却具有P-糖蛋白逆转多药耐药性的抑制剂。

更新日期：2017-08-10

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