Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.

衰老是疾病发展的最大风险因素。因此，了解调节衰老的生物分子和机制对于开发老年人健康最大化干预措施至关重要。传统上，脂肪对长寿的影响被认为是纯粹有害的。然而，新的研究开始揭示脂质作为信号分子对健康和长寿的可能有益影响。这些研究强调了衰老和脂质信号传导之间的复杂联系。在这篇综述中，我们总结了越来越多的证据，这些证据表明脂质代谢的变化，特别是脂质信号传导，是健康衰老的潜在机制。