Tumour cells are thought to avoid being phagocytosed through expression of the 'self' marker CD47, which ligates the macrophage receptor SIRPα. Alvey et al. investigated the potential of SIRPα-inhibited bone marrow-derived macrophages, primed with tumour-targeting antibodies, to clear tumours in vivo. Systemic injection

中文翻译：

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肿瘤免疫学：疯狂喂养

肿瘤细胞被认为避免通过连接巨噬细胞受体SIRPα的“自身”标记CD47的表达而被吞噬。Alvey等。研究了用靶向肿瘤的抗体引发的SIRPα抑制的骨髓来源的巨噬细胞在体内清除肿瘤的潜力。全身注射