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Neuroblastoma: Tumours get super-enhanced
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2017-07-25 , DOI: 10.1038/nrc.2017.56
Conor A. Bradley

Van Groningen et al. unravel the epigenetic nature of intratumoural heterogeneity in neuroblastoma, which comprises both lineage-committed adrenergic cells and undifferentiated mesenchymal cells that are defined by unique super-enhancer transcriptional networks and gene expression signatures.

中文翻译:

神经母细胞瘤:肿瘤变得超级增强

范格罗宁根(Van Groningen)等。揭示神经母细胞瘤中肿瘤内异质性的表观遗传学性质,它既包括沿袭组成的肾上腺素能细胞又包括未分化的间充质细胞,它们由独特的超级增强转录网络和基因表达特征所定义。
更新日期:2017-08-10
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