Van Groningen et al. unravel the epigenetic nature of intratumoural heterogeneity in neuroblastoma, which comprises both lineage-committed adrenergic cells and undifferentiated mesenchymal cells that are defined by unique super-enhancer transcriptional networks and gene expression signatures.

中文翻译：

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神经母细胞瘤：肿瘤变得超级增强

范格罗宁根（Van Groningen）等。揭示神经母细胞瘤中肿瘤内异质性的表观遗传学性质，它既包括沿袭组成的肾上腺素能细胞又包括未分化的间充质细胞，它们由独特的超级增强转录网络和基因表达特征所定义。