The incidence of allergic disease continues to rise in industrialized countries. The rapid increase in the incidence of allergic disease throughout the past half century suggests that recently altered environmental factors are driving allergy development. Accumulating evidence suggests that environmental experiences that occur during the first months of life can influence the risk of allergic sensitization. In this Review, we present the evidence relating to specific early life exposures that affect future allergy development, and discuss how these exposures may promote either tolerance or allergic sensitization.

中文翻译：

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影响过敏症发展的早期生活因素

在工业化国家，过敏性疾病的发病率持续上升。在过去的半个世纪中，过敏性疾病的发病率迅速增加，这表明最近改变的环境因素正在推动过敏的发展。越来越多的证据表明，在生命的头几个月中发生的环境经历可能会影响过敏性致敏的风险。在这篇综述中，我们提供了与特定的早期生命接触有关的证据，这些接触会影响未来的过敏发展，并讨论这些接触如何促进耐受性或过敏性致敏。