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Visible-Light-Induced Trifluoromethylation of Highly Functionalized Arenes and Heteroarenes in Continuous Flow
Synthesis ( IF 2.2 ) Pub Date : 2017-08-09 , DOI: 10.1055/s-0036-1588527
Jesus Alcazar 1 , Timothy Noёl 2 , Irini Abdiaj 1 , Cecilia Bottecchia 2
Affiliation  

Abstract

We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF3)ppy}2](dtbpy)]PF6 as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.

We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF3)ppy}2](dtbpy)]PF6 as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.



中文翻译:

可见光诱导的连续流动中高度官能化的芳烃和杂芳烃的三氟甲基化

摘要

我们报告连续流协议的芳烃,杂芳烃和苯并稠合的杂环三氟甲基化。该光氧化还原方法依赖于使用固体三氟甲烷亚磺酸钠(CF 3 SO 2 Na)作为三氟甲基化剂,以及使用铱络合物[Ir {dF(CF 3)ppy} 2 ](dtbpy)] PF 6作为光氧化还原催化剂。事实证明,各种高度官能化的杂环与该方法兼容,并且在停留时间30分钟内即可获得中等至良好的收率。

我们报告连续流协议的芳烃,杂芳烃和苯并稠合的杂环三氟甲基化。该光氧化还原方法依赖于使用固体三氟甲烷亚磺酸钠(CF 3 SO 2 Na)作为三氟甲基化剂,以及使用铱络合物[Ir {dF(CF 3)ppy} 2 ](dtbpy)] PF 6作为光氧化还原催化剂。事实证明,各种高度官能化的杂环与该方法兼容,并且在停留时间30分钟内即可获得中等至良好的收率。

更新日期:2017-08-09
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