Abstract

We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF₃SO₂Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF₃)ppy}₂](dtbpy)]PF₆ as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.

We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF₃SO₂Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF₃)ppy}₂](dtbpy)]PF₆ as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.

中文翻译：

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可见光诱导的连续流动中高度官能化的芳烃和杂芳烃的三氟甲基化

摘要

我们报告连续流协议的芳烃，杂芳烃和苯并稠合的杂环三氟甲基化。该光氧化还原方法依赖于使用固体三氟甲烷亚磺酸钠（CF ₃ SO ₂ Na）作为三氟甲基化剂，以及使用铱络合物[Ir {dF（CF ₃）ppy} ₂ ]（dtbpy）] PF ₆作为光氧化还原催化剂。事实证明，各种高度官能化的杂环与该方法兼容，并且在停留时间30分钟内即可获得中等至良好的收率。

我们报告连续流协议的芳烃，杂芳烃和苯并稠合的杂环三氟甲基化。该光氧化还原方法依赖于使用固体三氟甲烷亚磺酸钠（CF ₃ SO ₂ Na）作为三氟甲基化剂，以及使用铱络合物[Ir {dF（CF ₃）ppy} ₂ ]（dtbpy）] PF ₆作为光氧化还原催化剂。事实证明，各种高度官能化的杂环与该方法兼容，并且在停留时间30分钟内即可获得中等至良好的收率。