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Probing the Surfaces of Biomacromolecules with Polymer-Scaffolded Dynamic Combinatorial Libraries
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-08-09 00:00:00 , DOI: 10.1021/acsmacrolett.7b00561
Antonio J Ruiz-Sanchez 1 , Patrick L Higgs 1 , Daniel T Peters 2 , Andrew T Turley 1 , Matthew A Dobson 1 , Adam J North 1 , David A Fulton 1
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Methods to analyze and compare biomacromolecular surfaces are still in their relative infancy on account of the challenges involved in comparing surfaces computationally. We describe a systems chemistry approach that utilizes polymer-scaffolded dynamic combinatorial libraries to experimentally probe biomacromolecular surfaces in aqueous solution which provides feedback as to the nature of the surfaces, allowing the comparison of three globular proteins and a nucleic acid.

中文翻译:

用聚合物脚手架动态组合库探测生物大分子的表面

由于在计算上比较表面所涉及的挑战,分析和比较生物大分子表面的方法仍处于相对起步阶段。我们描述了一种系统化学方法,该方法利用聚合物支架动态组合库来实验探测水溶液中的生物大分子表面,从而提供关于表面性质的反馈,从而可以比较三种球状蛋白质和一种核酸。
更新日期:2017-08-09
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