Nanoelectronic Discrimination of Nonmalignant and Malignant Cells Using Nanotube Field-Effect Transistors,ACS Sensors

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Nanoelectronic Discrimination of Nonmalignant and Malignant Cells Using Nanotube Field-Effect Transistors
ACS Sensors ( IF 8.2 ) Pub Date : 2017-08-09 00:00:00 , DOI: 10.1021/acssensors.7b00383
Guilherme O. Silva _{1,

2} , Zachary P. Michael ₁ , Long Bian ₁ , Galina V. Shurin ₃ , Marcelo Mulato ₂ , Michael R. Shurin ₃ , Alexander Star ₁

Affiliation

Detection of malignant cells in tissue is a difficult hurdle in medical diagnostics and screening. Carbon nanotubes are extremely sensitive to their local environments, and nanotube-based field-effect transistors (NTFETs) provide a plethora of information regarding the mechanism of interaction with target analytes. Herein, we use a series of functionalized metal nanoparticle-decorated NTFET devices forming an array with multiple nonselective sensor units as the electronic “tongue”, sensing all five basic tastes. By extraction of selected NTFET characteristics and using linear discriminant analysis, we have successfully detected and discriminated between malignant and nonmalignant tissues and cells. We also studied the sensing mechanism and what NTFET characteristics are responsible for the variation of response between cell types, allowing for the design of future studies such as detection of malignant cells in a biopsy or the effects of malignant cells on healthy tissue.

中文翻译：

使用纳米管场效应晶体管对非恶性和恶性细胞进行纳米电子识别

在医学诊断和筛查中，检测组织中的恶性细胞是一个困难的障碍。碳纳米管对其本地环境极为敏感，基于纳米管的场效应晶体管（NTFET）提供了大量有关与目标分析物相互作用机理的信息。在本文中，我们使用一系列功能化的金属纳米粒子修饰的NTFET器件形成具有多个非选择性传感器单元的阵列作为电子“舌头”，从而感测所有五个基本口味。通过提取选定的NTFET特性并使用线性判别分析，我们已成功检测并区分了恶性和非恶性组织与细胞。我们还研究了感应机制以及哪些NTFET特性导致了电池类型之间的响应变化，

更新日期：2017-08-09

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