Tunable, Chemo- and Site-Selective Nitrene Transfer Reactions through the Rational Design of Silver(I) Catalysts,Accounts of Chemical Research

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Tunable, Chemo- and Site-Selective Nitrene Transfer Reactions through the Rational Design of Silver(I) Catalysts
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-08 00:00:00 , DOI: 10.1021/acs.accounts.7b00178
Juliet M. Alderson ₁ , Joshua R. Corbin ₁ , Jennifer M. Schomaker ₁

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Carbon–nitrogen (C–N) bonds are ubiquitous in pharmaceuticals, agrochemicals, diverse bioactive natural products, and ligands for transition metal catalysts. An effective strategy for introducing a new C–N bond into a molecule is through transition metal-catalyzed nitrene transfer chemistry. In these reactions, a metal–supported nitrene can either add across a C═C bond to form an aziridine or insert into a C–H bond to furnish the corresponding amine. Typical catalysts for nitrene transfer include Rh₂L_n and Ru₂L_n complexes supported by bridging carboxylate and related ligands, as well as complexes based on Cu, Co, Ir, Fe, and Mn supported by porphyrins and related ligands.

中文翻译：

通过合理设计银（I）催化剂进行可调的，化学的和选择性的硝基转移反应

碳氮键在制药，农用化学品，多种生物活性天然产物以及过渡金属催化剂的配体中无处不在。将新的C–N键引入分子的有效策略是通过过渡金属催化的腈转移化学。在这些反应中，金属负载的腈可以通过C═C键加成形成氮丙啶，也可以插入CH键以提供相应的胺。用于腈转移的典型催化剂包括通过桥接羧酸盐和相关配体负载的Rh ₂ L _n和Ru ₂ L _n配合物，以及由卟啉和相关配体负载的基于Cu，Co，Ir，Fe和Mn的配合物。

更新日期：2017-08-08

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