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Tunable, Chemo- and Site-Selective Nitrene Transfer Reactions through the Rational Design of Silver(I) Catalysts
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-08 00:00:00 , DOI: 10.1021/acs.accounts.7b00178
Juliet M. Alderson 1 , Joshua R. Corbin 1 , Jennifer M. Schomaker 1
Affiliation  

Carbon–nitrogen (C–N) bonds are ubiquitous in pharmaceuticals, agrochemicals, diverse bioactive natural products, and ligands for transition metal catalysts. An effective strategy for introducing a new C–N bond into a molecule is through transition metal-catalyzed nitrene transfer chemistry. In these reactions, a metal–supported nitrene can either add across a C═C bond to form an aziridine or insert into a C–H bond to furnish the corresponding amine. Typical catalysts for nitrene transfer include Rh2Ln and Ru2Ln complexes supported by bridging carboxylate and related ligands, as well as complexes based on Cu, Co, Ir, Fe, and Mn supported by porphyrins and related ligands.

中文翻译:

通过合理设计银(I)催化剂进行可调的,化学的和选择性的硝基转移反应

碳氮键在制药,农用化学品,多种生物活性天然产物以及过渡金属催化剂的配体中无处不在。将新的C–N键引入分子的有效策略是通过过渡金属催化的腈转移化学。在这些反应中,金属负载的腈可以通过C═C键加成形成氮丙啶,也可以插入CH键以提供相应的胺。用于腈转移的典型催化剂包括通过桥接羧酸盐和相关配体负载的Rh 2 L n和Ru 2 L n配合物,以及由卟啉和相关配体负载的基于Cu,Co,Ir,Fe和Mn的配合物。
更新日期:2017-08-08
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