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Graphene: A Versatile Platform for Nanotheranostics and Tissue Engineering
Progress in Materials Science ( IF 37.4 ) Pub Date : 2018-01-01 , DOI: 10.1016/j.pmatsci.2017.08.004
Renu Geetha Bai , Neethu Ninan , Kasturi Muthoosamy , Sivakumar Manickam

Abstract The sustained extensive research on graphene and its derivatives in the last decade portrayed its significance in the field of material science and carved its own niche in nanotechnology. Starting from the simple pencil, the role of graphene now extends to a lifesaver through innovations in nanomedicine specifically the early detection of abnormalities and efficient treatments. Graphene has the potential to satisfy the nanotechnological concepts of personalized and regenerative medicine for a disease-free future. The functionalization techniques ameliorate graphene for improved solubility, stability, loading capacity, etc. which makes it an ideal nanosystem for theranostic applications such as biosensing, drug delivery, gene therapy, bioimaging, phototherapy and hybrid theranostics. In addition, due to its electrically tunable surface chemistry, maximal surface-to-volume ratio, easy functionalization capacity and mechanical robustness, graphene gained enormous attention in tissue engineering specifically in cardiac, nerve, bone, skin and stem cells. This review focusses on the recent developments in graphene-based nanotheranostics and tissue engineering, which reveals the hidden potential of modern medical notions in efficiently handling the variety of abnormalities. Moreover, it raises the necessity of successful therapeutic systems to transfer from bench-to-bedside through clinical trials to enhance the current treatment scenario.

中文翻译:

石墨烯:用于纳米治疗学和组织工程的多功能平台

摘要 过去十年对石墨烯及其衍生物的持续广泛研究描绘了其在材料科学领域的重要性,并在纳米技术中占有一席之地。从简单的铅笔开始,石墨烯的作用现在通过纳米医学的创新扩展到救星,特别是早期检测异常和有效治疗。石墨烯有可能满足个性化和再生医学的纳米技术概念,以实现无病未来。功能化技术改善了石墨烯的溶解性、稳定性、负载能力等,使其成为生物传感、药物输送、基因治疗、生物成像、光疗和混合治疗诊断等治疗诊断应用的理想纳米系统。此外,由于其电可调的表面化学、最大的表面积与体积比、易于功能化的能力和机械强度,石墨烯在组织工程中特别是在心脏、神经、骨骼、皮肤和干细胞中获得了极大的关注。本综述重点关注基于石墨烯的纳米治疗学和组织工程的最新发展,揭示了现代医学观念在有效处理各种异常方面的潜在潜力。此外,它提出了成功的治疗系统的必要性,通过临床试验从工作台转移到床边,以增强当前的治疗方案。皮肤和干细胞。本综述重点关注基于石墨烯的纳米治疗学和组织工程的最新发展,揭示了现代医学观念在有效处理各种异常方面的潜在潜力。此外,它提出了成功的治疗系统的必要性,通过临床试验从工作台转移到床边,以增强当前的治疗方案。皮肤和干细胞。本综述重点关注基于石墨烯的纳米治疗学和组织工程的最新发展,揭示了现代医学观念在有效处理各种异常方面的潜在潜力。此外,它提出了成功的治疗系统的必要性,通过临床试验从工作台转移到床边,以增强当前的治疗方案。
更新日期:2018-01-01
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