A single molecular scaffold can be adapted to interact with diverse targets, either separately or simultaneously. Nucleosides and nucleotides in which ribose is substituted with bicyclo[3.1.0]hexane are an example of a versatile drug-like scaffold for increasing selectivity at their classical targets: kinases, polymerases, adenosine and P2 receptors. Also, by applying structure-based functional group manipulations, rigidified adenosine derivatives can be repurposed to satisfy pharmacophoric requirements of various GPCRs, ion channels, enzymes and transporters, initially detected as off-target activities. Recent examples include 5HT_2B serotonin receptor antagonists and novel dopamine transporter allosteric modulators. This directable target diversity establishes rigid nucleosides as privileged scaffolds.

单个分子支架可以单独或同时与不同的靶标相互作用。核糖被双环[3.1.0]己烷取代的核苷和核苷酸是多功能类药物支架的一个例子，用于提高其经典靶点的选择性：激酶、聚合酶、腺苷和P2受体。此外，通过应用基于结构的官能团操作，刚性化腺苷衍生物可以重新利用，以满足各种 GPCR、离子通道、酶和转运蛋白的药效学要求，最初检测为脱靶活性。最近的例子包括 5HT _2B血清素受体拮抗剂和新型多巴胺转运蛋白变构调节剂。这种可定向的靶标多样性将刚性核苷建立为优先支架。