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Endocrine disrupting potential of PAHs and their alkylated analogues associated with oil spills
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2017-07-18 00:00:00 , DOI: 10.1039/c7em00125h Sangwoo Lee 1, 2, 3, 4, 5 , Seongjin Hong 4, 6, 7, 8 , Xiaoshan Liu 1, 9, 10, 11 , Cheolmin Kim 1, 2, 3, 4 , Dawoon Jung 1, 2, 3, 4, 12 , Un Hyuk Yim 4, 13, 14, 15 , Won Joon Shim 4, 13, 14, 15 , Jong Seong Khim 2, 3, 4, 16, 17 , John P. Giesy 18, 19, 20, 21, 22 , Kyungho Choi 1, 2, 3, 4
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2017-07-18 00:00:00 , DOI: 10.1039/c7em00125h Sangwoo Lee 1, 2, 3, 4, 5 , Seongjin Hong 4, 6, 7, 8 , Xiaoshan Liu 1, 9, 10, 11 , Cheolmin Kim 1, 2, 3, 4 , Dawoon Jung 1, 2, 3, 4, 12 , Un Hyuk Yim 4, 13, 14, 15 , Won Joon Shim 4, 13, 14, 15 , Jong Seong Khim 2, 3, 4, 16, 17 , John P. Giesy 18, 19, 20, 21, 22 , Kyungho Choi 1, 2, 3, 4
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Polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs are known to be major toxic contaminants in spills of petroleum hydrocarbons (oil). Spilled oil undergoes weathering and over time, PAHs go through a series of compositional changes. PAHs can disrupt endocrine functions, and the type of functions affected and associated potencies vary with the type and alkylation status of PAH. In this study, the potential of five major PAHs of crude oil, i.e., naphthalene, fluorene, dibenzothiophene, phenanthrene, and chrysene, and their alkylated analogues (n = 25), to disrupt endocrine functions was evaluated by use of MVLN-luc and H295R cell lines. In the MVLN-luc bioassay, seven estrogen receptor (ER) agonists were detected among 30 tested PAHs. The greatest ER-mediated potency was observed for 1-methylchrysene (101.4%), followed by phenanthrene and its alkylated analogues (range of %-E2max from 1.6% to 47.3%). In the H295R bioassay, significantly greater syntheses of steroid hormones were observed for 20 PAHs. For major PAHs and their alkylated analogues, disruption of steroidogenesis appeared to be more significant than ER-mediated effects. The number and locations of alkyl-moieties alone could not explain differences in the types or the potencies of toxicities. This observation shows that disruption of endocrine functions by some constituents of oil spills could be underestimated if only parent compounds are considered in assessments of hazard and risk.
中文翻译：
与溢油有关的内分泌破坏PAHs及其烷基化类似物的潜力
已知多环芳烃（PAH）和烷基化PAH是石油烃（油）泄漏物中的主要有毒污染物。溢油会经受风化，随着时间的流逝，PAH会经历一系列的成分变化。PAHs会破坏内分泌功能，受影响的功能类型和相关效能会随PAH的类型和烷基化状态而变化。在这项研究中，原油，五大多环芳烃的电位即，萘，芴，二苯并噻吩，菲，和屈，和它们的烷基化类似物（Ñ = 25），以破坏内分泌功能通过使用MVLN-的评价LUC和H295R细胞系。在MVLN- luc中生物测定法中，在30个测试的PAH中检测到7种雌激素受体（ER）激动剂。观察到最大的ER介导效能为1-甲基丙烯（101.4％），其次为菲及其烷基化类似物（％-E2max范围从1.6％至47.3％）。在H295R生物测定中，观察到20个PAH的类固醇激素合成明显更高。对于主要的PAH及其烷基化类似物，类固醇生成的破坏似乎比ER介导的作用更为显着。单独的烷基部分的数目和位置不能解释毒性的类型或效力的差异。该观察结果表明，如果在危险和风险评估中仅考虑母体化合物，则漏油的某些成分对内分泌功能的破坏可能会被低估。
更新日期：2017-08-07
中文翻译：
与溢油有关的内分泌破坏PAHs及其烷基化类似物的潜力
已知多环芳烃（PAH）和烷基化PAH是石油烃（油）泄漏物中的主要有毒污染物。溢油会经受风化，随着时间的流逝，PAH会经历一系列的成分变化。PAHs会破坏内分泌功能，受影响的功能类型和相关效能会随PAH的类型和烷基化状态而变化。在这项研究中，原油，五大多环芳烃的电位即，萘，芴，二苯并噻吩，菲，和屈，和它们的烷基化类似物（Ñ = 25），以破坏内分泌功能通过使用MVLN-的评价LUC和H295R细胞系。在MVLN- luc中生物测定法中，在30个测试的PAH中检测到7种雌激素受体（ER）激动剂。观察到最大的ER介导效能为1-甲基丙烯（101.4％），其次为菲及其烷基化类似物（％-E2max范围从1.6％至47.3％）。在H295R生物测定中，观察到20个PAH的类固醇激素合成明显更高。对于主要的PAH及其烷基化类似物，类固醇生成的破坏似乎比ER介导的作用更为显着。单独的烷基部分的数目和位置不能解释毒性的类型或效力的差异。该观察结果表明，如果在危险和风险评估中仅考虑母体化合物，则漏油的某些成分对内分泌功能的破坏可能会被低估。
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