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Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates
ACS Medicinal Chemistry Letters ( IF 4.2 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1021/acsmedchemlett.7b00262 Gaia Fumagalli 1 , Barbara Stella 2 , Ievgenia Pastushenko 3 , Francesca Ricci 4 , Michael S. Christodoulou 1 , Giovanna Damia 4 , Davide Mazza 5, 6 , Silvia Arpicco 2 , Clelia Giannini 1 , Lavinia Morosi 7 , Franco Dosio 2 , Panagiota A. Sotiropoulou 3 , Daniele Passarella 1
ACS Medicinal Chemistry Letters ( IF 4.2 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1021/acsmedchemlett.7b00262 Gaia Fumagalli 1 , Barbara Stella 2 , Ievgenia Pastushenko 3 , Francesca Ricci 4 , Michael S. Christodoulou 1 , Giovanna Damia 4 , Davide Mazza 5, 6 , Silvia Arpicco 2 , Clelia Giannini 1 , Lavinia Morosi 7 , Franco Dosio 2 , Panagiota A. Sotiropoulou 3 , Daniele Passarella 1
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The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumor growth and toxicity of chemotherapy.
中文翻译：
通过阿霉素和环巴胺共轭物的自组装产生的杂纳米颗粒
介绍了用阿霉素（DOXO）和环巴胺（CYP）共轭物制备异质颗粒（NPs）的方法。对A431细胞系的生物学评估证实了亲本药物活性的维持。的体内研究显示，自组装纳米颗粒减少肿瘤生长和化学疗法的毒性。
更新日期：2017-08-07
中文翻译：
通过阿霉素和环巴胺共轭物的自组装产生的杂纳米颗粒
介绍了用阿霉素（DOXO）和环巴胺（CYP）共轭物制备异质颗粒（NPs）的方法。对A431细胞系的生物学评估证实了亲本药物活性的维持。的体内研究显示，自组装纳米颗粒减少肿瘤生长和化学疗法的毒性。
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