As the speed of chromatographic enantioseparations advances to the point where the enantiomers of most chiral compounds can be resolved in less than a minute, some in less than a second, we pose the question of how this field is likely to develop over the next few years. Are we approaching a fundamental speed limit, or will further technological advances continue to deliver faster and faster separations? Are faster separations even needed for chemical research, and if so, how will they help? We herein examine this trend, investigating the barriers that currently limit speed and offering some insights into the continued evolution of fast chromatographic enantioseparations.

中文翻译：

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我们是否正在达到对映异构体色谱分离的速度极限？

随着色谱对映体分离速度的加快，大多数手性化合物的对映体可以在不到一分钟的时间内分解，有些在不到一秒钟的时间内，我们提出了一个问题，即未来几年该领域将如何发展。我们是要达到基本的速度极限，还是进一步的技术进步会继续提供越来越快的分离效果？化学研究是否甚至需要更快的分离，如果需要，它们将如何提供帮助？我们在本文中研究了这种趋势，研究了目前限制速度的障碍，并对快速色谱对映异构体的持续发展提供了一些见识。