Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri,Journal of Natural Products

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Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00198
Fekadu-Roge Gobu ₁ , Jian-Jun Chen ₁ , Jun Zeng ₁ , Wen-Jun Wei ₁ , Wei-Feng Wang ₁ , Chang-Jun Lin ₁ , Kun Gao ₁

Affiliation

Six new (1–3 and 6–8) and seven known diterpenoids were isolated from the whole plant of Ligularia fischeri. Compound 1 is a new 15,16-dinorerythroxylane-type diterpenoid possessing a C₁₈ skeleton, and 2 is the first example of a 6/6/6/6/5/5-fused hexacyclic ent-kaurane diterpenoid with 19,20-olide and 11,16-epoxy moieties. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The absolute configurations of 1 and 7 were determined by single-crystal X-ray diffraction. Compounds 1–13 were evaluated for their immunosuppressive activity, and 4, 7, and 13 showed moderate inhibitory activities against human B lymphoblast HMy2.CIR cells with IC₅₀ values of 56.3 ± 2.2, 13.3 ± 0.8, and 31.4 ± 0.9 μM, respectively.

中文翻译：

分离，结构Elucidition，并从二萜的免疫抑制作用的蹄叶橐吾

六个新的（1 - 3和6 - 8）和七个已知二萜类化合物是从全植物中分离蹄叶橐吾。化合物1是一种新的15,16- dinorerythroxylane型二萜类具有一个C ₁₈骨架，2是一个6/6/6/6/10/10 -稠合六环的第一示例ENT -kaurane二萜与19,20-内酰胺和11,16-环氧部分。通过光谱分析和化学方法阐明了新化合物的结构。1和7的绝对构型通过单晶X射线衍射确定。化合物1 –13它们的免疫抑制活性进行评价，4，7，和13显示出对人B中等抑制活性的淋巴母细胞HMy2.CIR与IC _50倍的56.3±2.2，13.3±0.8的值，和31.4±0.9μM，分别。

更新日期：2017-08-07

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