Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line,Journal of Natural Products

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Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00375
Hai X. Nguyen , Mai T. T. Nguyen , Nhan T. Nguyen , Suresh Awale ₁

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The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC₅₀ value of 14.0 μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (1–5), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC₅₀ values of 4.3 and 3.7 μM, respectively.

中文翻译：

越南Trigona小蜂胶的化学成分及其对PANC-1人胰腺癌细胞系的抗紧缩活性

越南无刺蜂Trigona minor蜂胶的乙醇提取物在营养缺乏的培养基中对PANC-1人胰腺癌细胞具有强大的优先细胞毒性，PC ₅₀值为14.0μg/ mL。该提取物的化学调查导致的15环阿屯烷型三萜类化合物的分离，其中包括五个新的化合物（15），和一个羊毛甾烷型三萜类化合物。在NMR光谱分析的基础上阐明了新化合物的结构。在分离出的化合物中，23-羟基异芒果酸B（5）和27-羟基异芒果酸（13）在营养剥夺的条件下对PANC-1人胰腺癌细胞表现出最有效的优先细胞毒性，PC ₅₀值分别为4.3和3.7μM。

更新日期：2017-08-07

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