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Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00375
Hai X. Nguyen , Mai T. T. Nguyen , Nhan T. Nguyen , Suresh Awale 1
Affiliation  

The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC50 value of 14.0 μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (15), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 4.3 and 3.7 μM, respectively.

中文翻译:

越南Trigona小蜂胶的化学成分及其对PANC-1人胰腺癌细胞系的抗紧缩活性

越南无刺蜂Trigona minor蜂胶的乙醇提取物在营养缺乏的培养基中对PANC-1人胰腺癌细胞具有强大的优先细胞毒性,PC 50值为14.0μg/ mL。该提取物的化学调查导致的15环阿屯烷型三萜类化合物的分离,其中包括五个新的化合物(15),和一个羊毛甾烷型三萜类化合物。在NMR光谱分析的基础上阐明了新化合物的结构。在分离出的化合物中,23-羟基异芒果酸B(5)和27-羟基异芒果酸(13)在营养剥夺的条件下对PANC-1人胰腺癌细胞表现出最有效的优先细胞毒性,PC 50值分别为4.3和3.7μM。
更新日期:2017-08-07
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