Abstract

A method for the synthesis of gem-difluorohomoallylic alcohols by the substitution of iodine in the iododifluoromethyl group by a vinyl fragment is described. The reaction proceeds via an intramolecular iodine atom transfer followed by β-elimination. The reaction is performed in the presence of an iridium photocatalyst, fac-Ir(ppy)₃, and triphenylphosphine under irradiation with light-emitting diodes.

A method for the synthesis of gem-difluorohomoallylic alcohols by the substitution of iodine in the iododifluoromethyl group by a vinyl fragment is described. The reaction proceeds via an intramolecular iodine atom transfer followed by β-elimination. The reaction is performed in the presence of an iridium photocatalyst, fac-Ir(ppy)₃, and triphenylphosphine under irradiation with light-emitting diodes.

中文翻译：

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通过光促进的分子内原子转移反应使碘二氟甲基化的醇乙烯基化

摘要

描述了通过用乙烯基片段取代碘二氟甲基中的碘来合成宝石-二氟均烯丙基醇的方法。该反应通过分子内碘原子转移然后进行β-消除进行。该反应在铱光催化剂，fac -Ir（ppy）₃和三苯膦的存在下，在用发光二极管照射下进行。

描述了通过用乙烯基片段取代碘二氟甲基中的碘来合成宝石-二氟均烯丙基醇的方法。该反应通过分子内碘原子转移然后进行β-消除进行。该反应在铱光催化剂，fac -Ir（ppy）₃和三苯膦的存在下，在用发光二极管照射下进行。