In mice, the first (1st) and second (2nd) polar bodies (PBs) can be used in place of the female genome of oocytes or zygotes and efficiently support the generation of embryonic stem cells (ESCs) and normal offspring1,2,3. These results indicate that both 1st and 2nd PBs can be used as nuclear donors for mitochondrial replacement therapy (MRT)4, which is an effective approach for preventing the transmission of disease-causing mutant mitochondria from mother to children5.

中文翻译：

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极体是人类胚胎重建的有效供体，可用于潜在的线粒体替代治疗

在小鼠中，第一（第一）和第二（第二）极体（PBs）可以用来代替卵母细胞或合子的雌性基因组，并有效地支持胚胎干细胞（ESC）和正常后代1,2,3的生成。这些结果表明，第1和第2 PB均可用作线粒体替代疗法（MRT）4的核供体，这是防止致病突变线粒体从母亲向儿童传播的有效方法5。