Abstract

Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5-exo-dig cyclization.

Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5-exo-dig cyclization.

中文翻译：

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钯催化的2-溴芳基羰基的无铜Sonogashira偶联：通过一锅还原环化反应合成异苯并呋喃

摘要

提出了钯催化的2-溴羰基无铜Sonogashira偶联。该方法提供了2-炔​​基芳基羰基，它们是用于完成许多碳环和杂环基序的有用的合成子。重要的是，该策略扩展到通过还原然后分子内5- exo- dig环化的一锅法合成异苯并呋喃。

提出了钯催化的2-溴羰基无铜Sonogashira偶联。该方法提供了2-炔​​基芳基羰基，它们是用于完成许多碳环和杂环基序的有用的合成子。重要的是，该策略扩展到通过还原然后分子内5- exo- dig环化的一锅法合成异苯并呋喃。