The originally proposed structure of astakolactin was revised, and an asymmetric total synthesis of the newly proposed structure was achieved. The key transformations in the synthesis were a Johnson–Claisen rearrangement, an asymmetric Mukaiyama aldol reaction, and a Mitsunobu-type cyclodehydration. The spectroscopic data and specific rotation of the compound obtained matched well with those reported for naturally occurring astakolactin.

中文翻译：

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（-）-Astakolactin的不对称全合成及其立体结构的确认

修改了最初提出的黄体泌乳素的结构，并实现了新提出结构的不对称全合成。合成过程中的关键转变是Johnson-Claisen重排，不对称的Mukaiyama aldol反应和Mitsunobu型环脱水。所获得化合物的光谱数据和比旋光度与报道的天然存在的astakolactin的光谱数据和比旋光度非常匹配。