Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.

中文翻译：

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间质干细胞在纤维化疾病中的作用。

纤维化与器官衰竭和高死亡率有关，并且通常以异常的成肌纤维细胞积累为特征。因此，研究成肌纤维细胞在各种疾病中的细胞起源是开发靶向抗纤维化治疗的有前途的策略。使用遗传谱系追踪技术的最新研究表明，在纤维化发展过程中，成肌纤维细胞生成过程中涉及多种器官驻留的血管周间充质干细胞（MSC）样细胞和骨髓MSC。在这篇综述中，我们概述了MSCs和MSC类细胞在肌成纤维细胞介导的肾，肺，心脏，肝脏，皮肤和骨髓纤维化疾病中的新兴作用。