The Fe isotopic composition of an individual's whole blood has recently been shown to be an interesting clinical indicator of Fe status. The present study aimed to evaluate the influence of several endemic characteristics of a representative population of the South Kivu province, an Fe-rich volcanic African region, on the whole blood Fe isotopic composition. Both diabetes mellitus and the ferroportin Q248H mutation are very common in Africa and are strongly associated with impairments in Fe metabolism. Fe isotopic analysis of whole blood samples was carried out using multi-collector inductively coupled plasma-mass spectrometry (after chromatographic isolation of the target element). Forty-two male subjects (between 48 and 59 years old) living in Bukavu (South Kivu) were enrolled in this study. Among the selected population, wild-type subjects and subjects presenting the ferroportin Q248H mutation (heterozygotes and homozygotes) were included. Within each group, diabetic and non-diabetic patients were considered. The whole blood δ⁵⁶Fe value ranged from −3.09‰ to −2.41‰. The δ⁵⁶Fe value shows a significant negative correlation with the ferritin concentration. No correlation could be established between the whole blood δ⁵⁶Fe value and the transferrin concentration, transferrin saturation or serum Fe concentration. The ferroportin Q248H mutation did not seem to have affected the whole blood Fe isotopic signature. The whole blood δ⁵⁶Fe values were significantly higher in diabetic subjects than in non-diabetic subjects and showed a significant negative correlation with body mass index (BMI) values.

中文翻译：

---

撒哈拉以南非洲人群的全血铁同位素特征

最近，已显示出个人全血中的铁同位素组成是一种有趣的铁状态临床指标。本研究旨在评估富铁火山非洲地区南基伍省的代表性种群的几种地方病特征对全血铁同位素组成的影响。糖尿病和铁转运蛋白Q248H突变在非洲都很常见，并且与铁代谢受损密切相关。使用多收集器电感耦合等离子体质谱法（在色谱分离目标元素后）进行全血样品的铁同位素分析。这项研究纳入了居住在布卡武（南基伍）的四十二名男性受试者（年龄在48至59岁之间）。在选定的人群中，包括野生型受试者和出现铁转运蛋白Q248H突变的受试者（杂合子和纯合子）。在每组中，考虑糖尿病和非糖尿病患者。全血δ⁵⁶ Fe值在-3.09‰至-2.41‰之间。的δ ⁵⁶ FE值示出了具有铁蛋白浓度的显著负相关。没有相关性可以在全血δ之间建立⁵⁶的Fe值和转铁蛋白浓度，铁蛋白饱和度或血清Fe浓度。铁转运蛋白Q248H突变似乎并未影响全血Fe同位素特征。全血δ ^56点的Fe的值在糖尿病受试者显著高于非糖尿病患者和表现出与身体质量指数（BMI）值的显著负相关。