Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with peroxidase mimicking activities because of their promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots of functional nanomaterials have been used to mimic peroxidase. However, few studies have focused on the Ni-based nanomaterials for peroxidase mimics. In this work, we obtained the porous LaNiO₃ nanocubes with high peroxidase-like activity by inducing its 3+ oxidation state in LaNiO₃ perovskite and optimizing the morphology of LaNiO₃ perovskite. The peroxidase mimicking activity of the porous LaNiO₃ nanocubes with Ni³⁺ was about 58~fold and 22~fold higher than that of NiO with Ni²⁺ and Ni nanoparticles with Ni⁰. More, the porous LaNiO₃ nanocubes exhibited about 2-fold higher activity when compared with LaNiO₃ nanoparticles. Based on the superior peroxidase-like activity of porous LaNiO₃ nanocubes, facile colorimetric assays for H₂O₂, glucose, and sarcosine detection were developed. Our present work not only demonstrates a useful strategy for modulating nanozymes' activities but also provides promising bioassays for clinical diagnostics.

中文翻译：

---

通过在LaNiO ₃钙钛矿中诱导3+氧化态来增强纳米结构镍的过氧化物酶样活性及其在生物医学测定中的应用

具有固有酶样活性的催化纳米材料，称为纳米酶，由于其相对于天然酶和常规人工酶的独特优势，最近引起了广泛的研究兴趣。在已开发的纳米酶中，由于其在生物传感，生物成像，生物医学等方面的应用前景广阔，因此特别关注具有过氧化物酶模拟活性的纳米酶。到目前为止，许多功能纳米材料已被用于模拟过氧化物酶。然而，很少有研究集中在用于过氧化物酶模拟的镍基纳米材料上。在这项工作中，我们通过在LaNiO ₃钙钛矿中诱导其3+氧化态并优化LaNiO的形态，获得了具有高过氧化物酶样活性的多孔LaNiO ₃纳米立方体。₃钙钛矿。具有Ni ³⁺的多孔LaNiO ₃纳米立方体的过氧化物酶模拟活性比具有Ni ²⁺的NiO和具有Ni ^0的Ni纳米颗粒的过氧化物酶活性高约58倍和22倍。更，多孔的LaNiO ₃纳米立方体表现出约2倍时的LaNiO相比更高的活性₃纳米颗粒。基于多孔LaNiO ₃纳米立方体的优异的过氧化物酶样活性，H ₂ O _2的简便比色测定，开发了葡萄糖和肌氨酸检测技术。我们目前的工作不仅证明了调节纳米酶活性的有用策略，而且还为临床诊断提供了有希望的生物测定方法。