Synthesis ( IF 2.2 ) Pub Date : 2017-07-31 , DOI: 10.1055/s-0036-1588501 Selvam Raju, Pratheepkumar Annamalai, Fu-Wei Chan, Po-Yen Tseng, Po-Yen Chen, Ting-Shen Kuo, Shih-Ching Chuang
Abstract
An efficient palladium-catalyzed addition reaction of alkyl- and arylsulfonic acids to propiolate esters to yield alkenyl sulfonates is demonstrated. The formation of alkenyl sulfonates is highly regio- and stereoselective with favorable yields of up to 95%, and two of the alkenyl sulfonates are utilized for a Sonogashira cross-coupling reaction to produce (Z)-1,3-enynoates.
An efficient palladium-catalyzed addition reaction of alkyl- and arylsulfonic acids to propiolate esters to yield alkenyl sulfonates is demonstrated. The formation of alkenyl sulfonates is highly regio- and stereoselective with favorable yields of up to 95%, and two of the alkenyl sulfonates are utilized for a Sonogashira cross-coupling reaction to produce (Z)-1,3-enynoates.
中文翻译:
钯催化丙二酸酯的区域和立体选择性氢磺化
摘要
证明了烷基和芳基磺酸的有效钯催化加成反应以丙酸酯化以产生烯基磺酸盐。烯基磺酸盐的形成具有很高的区域选择性和立体选择性,产率高达95%,并且其中两个烯基磺酸盐用于Sonogashira交叉偶联反应,生成(Z)-1,3-烯醇盐。
证明了烷基和芳基磺酸的有效钯催化加成反应以丙酸酯化以产生烯基磺酸盐。烯基磺酸盐的形成具有很高的区域选择性和立体选择性,产率高达95%,并且其中两个烯基磺酸盐用于Sonogashira交叉偶联反应,生成(Z)-1,3-烯醇盐。