Quaternized Polymer–Single-Walled Carbon Nanotube Scaffolds for a Chemiresistive Glucose Sensor,ACS Sensors

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Quaternized Polymer–Single-Walled Carbon Nanotube Scaffolds for a Chemiresistive Glucose Sensor
ACS Sensors ( IF 8.2 ) Pub Date : 2017-07-31 00:00:00 , DOI: 10.1021/acssensors.7b00323
Saniye Soylemez _{1,

2} , Bora Yoon _{1,

3} , Levent Toppare ₂ , Timothy M. Swager ₁

Affiliation

A chemiresistive glucose sensor based on poly(4-vinylpyridine) (P4VP) and single-walled carbon nanotube (SWCNT) composites was reported. To fabricate this glucose sensor, a glass substrate containing gold electrodes was treated with 3-bromopropyltrichlorosilane to obtain a covalent bonding between the polymer–SWCNT composite and the glass substrate. Some of the pyridyl moieties in P4VP react with the surface, and the remainders were quaternized using 2-bromoethanol to achieve highly charged hydrophilic surface with improved biocompatibility with enzyme molecules. The resulting biomimetic surface was functionalized with glucose oxidase (GOx) by electrostatic assembly with the quaternized P4VP-SWCNT composite. This material displays a decrease in electrical resistance as a result of enzymatically liberated hydrogen peroxide produced in response to glucose, which increases the p-doping of the SWCNT. The sensor exhibited high selectivity for glucose and showed an instant response (within 3 s) to glucose.

中文翻译：

季铵化聚合物-单壁碳纳米管支架，用于化学阻性葡萄糖传感器。

报道了一种基于聚（4-乙烯基吡啶）（P4VP）和单壁碳纳米管（SWCNT）复合材料的化学葡萄糖传感器。为了制造这种葡萄糖传感器，将含有金电极的玻璃基板用3-溴丙基三氯硅烷处理，以在聚合物-SWCNT复合材料和玻璃基板之间获得共价键。P4VP中的一些吡啶基部分与表面反应，其余部分则使用2-溴乙醇进行季铵化，从而获得带高电荷的亲水性表面，并改善了与酶分子的生物相容性。通过与季铵化的P4VP-SWCNT复合材料进行静电组装，将所得的仿生表面用葡萄糖氧化酶（GOx）功能化。该材料由于响应于葡萄糖产生的酶促释放的过氧化氢而显示出电阻的降低，这增加了SWCNT的p掺杂。该传感器对葡萄糖表现出高选择性，并显示了对葡萄糖的即时响应（在3 s内）。

更新日期：2017-07-31

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