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Organelle biogenesis in the endoplasmic reticulum
Nature Cell Biology ( IF 21.3 ) Pub Date : 2017-07-17 00:00:00 , DOI: 10.1038/ncb3579
Amit S. Joshi , Hong Zhang , William A. Prinz

Understanding organelle biogenesis is a central focus of cell biology. Whereas some are generated from existing organelles, others can be generated de novo. Most de novo organelle biogenesis occurs in the endoplasmic reticulum (ER). Here, we review the role of the ER in the generation of peroxisomes, lipid droplets, and omegasomes, which are platforms for autophagosome production, and discuss how ER subdomains with specific protein and lipid composition form and promote organelle biogenesis.

中文翻译:

内质网中的细胞器生物发生

了解细胞器的生物发生是细胞生物学的重点。有些是从现有的细胞器产生的,而另一些则可以从头产生。多数新生细胞器生物发生在内质网(ER)中。在这里,我们审查了ER在过氧化物酶体,脂质滴和ω体(它们是自噬体生产的平台)的产生中的作用,并讨论了具有特定蛋白质和脂质组成的ER亚域如何形成并促进细胞器的生物发生。
更新日期:2017-07-30
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