CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

中文翻译：

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CTCF围墙是好邻居。

CCCTC结合因子（CTCF）站点在拓扑相关域（TAD）的边界处富集，但尚不清楚它们在TAD中的功能。现在显示去除邻近α-珠蛋白增强子的亚TAD CTCF位点会导致邻近基因的不适当活化。TAD内增强剂的绝缘对于增强剂的组织特异性可能具有广泛的重要性。