Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression.

中文翻译：

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肥胖通过IL5和GM-CSF改变了肺髓细胞的细胞分布，从而增强了乳腺癌的转移

肥胖与慢性低度炎症有关，它可以破坏组织微环境内的体内平衡。考虑到肥胖与癌症死亡的相对风险之间的相关性，我们研究了肥胖相关的炎症是否促进转移性进展。我们证明，肥胖会导致正常小鼠中的肺中性粒细胞增多，原发肿瘤的存在会进一步加剧肥胖。肺中性粒细胞的增加以依赖GM-CSF和IL5的方式转化为乳腺癌向该部位转移的增加。重要的是，体重减轻足以逆转这种效应，并在小鼠模型和人类中均降低血清GM-CSF和IL5的水平。我们的数据表明，对肥胖患者人群的特殊考虑对于有效控制癌症进展至关重要。