Infections caused by multidrug resistant Klebsiella pneumoniae that produce K. pneumoniae carbapenemase (KPC) typically require treatment with two or more antimicrobial agents. Although carbapenems are hydrolyzed by KPCs, combined therapy with a carbapenem and a polymyxin (colistin or polymyxin B) significantly lowers mortality in critically ill patients infected with polymyxin-susceptible K. pneumoniae

中文翻译：

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美罗培南MIC对美罗培南和多粘菌素B联合杀灭KPC的肺炎克雷伯菌的杀伤活性

产生肺炎克雷伯菌碳青霉烯酶（KPC）的由多重耐药性肺炎克雷伯菌引起的感染通常需要使用两种或多种抗菌剂进行治疗。尽管碳青霉烯类被KPC水解，但将碳青霉烯类和多粘菌素（colistin或多粘菌素B）联合治疗可显着降低感染了多粘菌素的肺炎克雷伯菌的重症患者的死亡率。