The emergence and spread of bacteria with resistance to antibacterial drugs in recent years is now considered a significant threat to global public health and the world economy.^{1, 2} In particular, the severe bacterial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa have become serious clinical problems because of increased antimicrobial resistance, as observed for vancomycin-resistant S. aureus and multi-drug resistant P. aeruginosa

中文翻译：

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发现2-羟基arbekacin，一种新的氨基糖苷类抗生素，具有降低的肾毒性

近年来，对抗菌药物具有耐药性的细菌的出现和传播现在被认为是对全球公共卫生和世界经济的重大威胁。^1,2，特别是，耐甲氧西林金黄色葡萄球菌（MRSA）和铜绿假单胞菌引起的严重细菌感染由于耐药性增加而成为严重的临床问题，如耐万古霉素的金黄色葡萄球菌和耐多种药物的P.铜绿