Oxidative damage and inflammation have been identified, through clinical and preclinical studies, as the main causes of nonhealing chronic wounds. Reduction of persistent chronic inflammation by application of antioxidant and anti-inflammatory agents such as curcumin has been well studied. However, low aqueous solubility, poor tissue absorption, rapid metabolism and short plasma half-life have made curcumin unsuitable for systemic administration for better wound healing. Recently, various topical formulations of curcumin such as films, fibers, emulsion, hydrogels and different nanoformulations have been developed for targeted delivery of curcumin at wounded sites. In this review, we summarize and discuss different topical formulations of curcumin with emphasis on their wound-healing properties in animal models.

通过临床和临床前研究已确定氧化损伤和炎症是慢性伤口无法愈合的主要原因。通过使用抗氧化剂和消炎药（如姜黄素）减轻持续性慢性炎症的方法已有很好的研究。然而，低的水溶性，差的组织吸收，快速的代谢和短的血浆半衰期使得姜黄素不适合全身给药以更好地伤口愈合。近来，已经开发了姜黄素的各种局部制剂，例如膜，纤维，乳剂，水凝胶和不同的纳米制剂，用于在受伤部位靶向递送姜黄素。在这篇综述中，我们总结并讨论了姜黄素的不同局部用药配方，重点是它们在动物模型中的伤口愈合特性。