1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.

中文翻译：

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1,2,3-三唑环在药物化学中作为生物等排体

1,2,3-三唑是一种众所周知的支架，它广泛存在于以多种生物活性为特征的不同化合物中，例如抗微生物，抗病毒和抗肿瘤作用。此外，1,2,3-三唑的结构特征使其能够模拟不同的官能团，证明其广泛用作生物等位基因来合成新的活性分子。在这里，我们概述了1,2,3-三唑环作为设计药物类似物的生物等排体，重点介绍了相关的最新实例。