Progranulin is a cysteine-rich secreted protein with diverse pleiotropic actions and participates in several processes, such as inflammation or tumorigenesis. Progranulin was first identified as a growth factor and, recently, it was characterised as an adipokine implicated in obesity, insulin resistance and rheumatic disease. At a central level, progranulin acts as a neurotropic and neuroprotective factor and protects from neural degeneration. In this review, we summarise the most recent research advances concerning the potential role of progranulin as a therapeutic target and biomarker in cancer, neurodegenerative and inflammatory diseases.

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前颗粒蛋白作为生物标志物和潜在的治疗剂

前颗粒蛋白是富含半胱氨酸的分泌蛋白，具有多种多效作用，并参与多种过程，例如炎症或肿瘤发生。前颗粒蛋白最初被确定为生长因子，最近被表征为与肥胖，胰岛素抵抗和风湿性疾病有关的脂肪因子。在中央水平，前颗粒蛋白可作为一种神经营养和神经保护因子，可防止神经退行性变。在这篇综述中，我们总结了有关前颗粒蛋白在癌症，神经退行性疾病和炎性疾病中作为治疗靶标和生物标志物的潜在作用的最新研究进展。