The tumor vasculature transports oxygen, nutrients and drugs for crucial roles in tumor therapy. Antivascular therapy directly targets existing tumor vessels to reduce blood perfusion and then inhibit tumor growth. Vascular disrupting agents and ultrasound-stimulated microbubble destruction use chemical toxicity and physical effect, respectively, to damage vascular endothelial cells for antivascular therapy. Moreover, antivascular therapy can break vessel wall barriers and change the tumor microenvironment to compensate for the limitations of conventional chemotherapy or radiotherapy. This review presents current progress and an overview of antivascular therapy, which can inform the development and application in cancer research.

肿瘤脉管系统运输氧气，营养物质和药物，从而在肿瘤治疗中发挥关键作用。抗血管治疗直接针对现有的肿瘤血管，以减少血液灌注，然后抑制肿瘤的生长。血管破坏剂和超声刺激的微泡破坏分别利用化学毒性和物理作用来破坏血管内皮细胞以进行抗血管治疗。此外，抗血管治疗可打破血管壁屏障并改变肿瘤的微环境，以弥补常规化学疗法或放射疗法的局限性。这篇综述介绍了抗血管治疗的最新进展和概况，可以为癌症研究的发展和应用提供参考。