Electrospun polymeric micro/nanofibrous scaffolds have been investigated extensively as drug delivery platforms capable of controlled and sustained release of therapeutic agents in situ. Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.

电纺聚合物微/纳米纤维支架已被广泛研究为能够在原位控制和持续释放治疗剂的药物递送平台。这样的支架表现出优异的物理化学和生物学特性，并且可以以受控的方式包封和释放各种药物。本文回顾了用于长期释放药物的电纺支架的设计和制造方面的最新进展，特别强调了聚合物的选择，掺入药物的类型和最新的载药技术。最后，讨论了这种装置在需要有效和持续药物作用的创伤或疾病状态下的应用，并在其生物医学背景下进行了严格的评估。