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Sequence-Specific β-Peptide Synthesis by a Rotaxane-Based Molecular Machine
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-07-26 00:00:00 , DOI: 10.1021/jacs.7b05850
Guillaume De Bo 1 , Malcolm A. Y. Gall 1 , Matthew O. Kitching 1 , Sonja Kuschel 1 , David A. Leigh 1 , Daniel J. Tetlow 1 , John W. Ward 1
Affiliation  

We report on the synthesis and operation of a three-barrier, rotaxane-based, artificial molecular machine capable of sequence-specific β-homo (β3) peptide synthesis. The machine utilizes nonproteinogenic β3-amino acids, a class of amino acids not generally accepted by the ribosome, particularly consecutively. Successful operation of the machine via native chemical ligation (NCL) demonstrates that even challenging 15- and 19-membered ligation transition states are suitable for information translation using this artificial molecular machine. The peptide-bond-forming catalyst region can be removed from the transcribed peptide by peptidases, artificial and biomachines working in concert to generate a product that cannot be made by either machine alone.

中文翻译:

基于轮烷的分子机器合成特定序列的β-肽

我们在三势垒,基于轮烷-,人造分子能够特异性序列-β-HOMO(β的机器的合成和操作报告3)肽合成。该机器利用nonproteinogenicβ 3 -氨基酸,一类一般不为核糖体所接受,特别是连续的氨基酸。通过天然化学连接(NCL)成功操作机器表明,即使具有挑战性的15和19元连接转变状态也适合使用此人工分子机器进行信息翻译。可以通过肽酶,人工和生物机器协同工作,从转录的肽中除去形成肽键的催化剂区域,以产生不能由任何一种机器单独制造的产物。
更新日期:2017-07-28
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