Sequence-Specific β-Peptide Synthesis by a Rotaxane-Based Molecular Machine,Journal of the American Chemical Society

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Sequence-Specific β-Peptide Synthesis by a Rotaxane-Based Molecular Machine
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-07-26 00:00:00 , DOI: 10.1021/jacs.7b05850
Guillaume De Bo ₁ , Malcolm A. Y. Gall ₁ , Matthew O. Kitching ₁ , Sonja Kuschel ₁ , David A. Leigh ₁ , Daniel J. Tetlow ₁ , John W. Ward ₁

Affiliation

We report on the synthesis and operation of a three-barrier, rotaxane-based, artificial molecular machine capable of sequence-specific β-homo (β³) peptide synthesis. The machine utilizes nonproteinogenic β³-amino acids, a class of amino acids not generally accepted by the ribosome, particularly consecutively. Successful operation of the machine via native chemical ligation (NCL) demonstrates that even challenging 15- and 19-membered ligation transition states are suitable for information translation using this artificial molecular machine. The peptide-bond-forming catalyst region can be removed from the transcribed peptide by peptidases, artificial and biomachines working in concert to generate a product that cannot be made by either machine alone.

中文翻译：

基于轮烷的分子机器合成特定序列的β-肽

我们在三势垒，基于轮烷-，人造分子能够特异性序列-β-HOMO（β的机器的合成和操作报告³）肽合成。该机器利用nonproteinogenicβ ³ -氨基酸，一类一般不为核糖体所接受，特别是连续的氨基酸。通过天然化学连接（NCL）成功操作机器表明，即使具有挑战性的15和19元连接转变状态也适合使用此人工分子机器进行信息翻译。可以通过肽酶，人工和生物机器协同工作，从转录的肽中除去形成肽键的催化剂区域，以产生不能由任何一种机器单独制造的产物。

更新日期：2017-07-28

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