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DNA’s Chiral Spine of Hydration
ACS Central Science ( IF 12.7 ) Pub Date : 2017-05-24 00:00:00 , DOI: 10.1021/acscentsci.7b00100 M. Luke McDermott 1 , Heather Vanselous 1 , Steven A. Corcelli 2 , Poul B. Petersen 1
ACS Central Science ( IF 12.7 ) Pub Date : 2017-05-24 00:00:00 , DOI: 10.1021/acscentsci.7b00100 M. Luke McDermott 1 , Heather Vanselous 1 , Steven A. Corcelli 2 , Poul B. Petersen 1
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The iconic helical structure of DNA is stabilized by the solvation environment, where a change in the hydration state can lead to dramatic changes to the DNA structure. X-ray diffraction experiments at cryogenic temperatures have shown crystallographic water molecules in the minor groove of DNA, which has led to the notion of a spine of hydration of DNA. Here, chiral nonlinear vibrational spectroscopy of two DNA sequences shows that not only do such structural water molecules exist in solution at ambient conditions but that they form a chiral superstructure: a chiral spine of hydration. This is the first observation of a chiral water superstructure templated by a biomolecule. While the biological relevance of a chiral spine of hydration is unknown, the method provides a direct way to interrogate the properties of the hydration environment of DNA and water in biological settings without the use of labels.
中文翻译：
DNA的水合手性脊柱
DNA的标志性螺旋结构通过溶剂化环境得以稳定，其中水合状态的变化会导致DNA结构的剧烈变化。低温下的X射线衍射实验表明，在DNA的小沟中有结晶水分子，这导致了DNA的水合脊柱的概念。在这里，两个DNA序列的手性非线性振动光谱表明，不仅这种结构水分子在环境条件下存在于溶液中，而且它们还形成了手性超结构：水合的手性脊柱。这是对以生物分子为模板的手性水超结构的首次观察。尽管水合手性脊柱的生物学相关性尚不清楚，
更新日期：2017-07-28
中文翻译：
DNA的水合手性脊柱
DNA的标志性螺旋结构通过溶剂化环境得以稳定，其中水合状态的变化会导致DNA结构的剧烈变化。低温下的X射线衍射实验表明，在DNA的小沟中有结晶水分子，这导致了DNA的水合脊柱的概念。在这里，两个DNA序列的手性非线性振动光谱表明，不仅这种结构水分子在环境条件下存在于溶液中，而且它们还形成了手性超结构：水合的手性脊柱。这是对以生物分子为模板的手性水超结构的首次观察。尽管水合手性脊柱的生物学相关性尚不清楚，
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