Loss of inhibition in a circuit in the primary somatosensory cortex that controls the activity of layer 5 neurons drives pain hypersensitivity. Restoring this inhibition resets the inhibitory–excitatory balance, producing analgesia.

中文翻译：

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VIP皮质导体为慢性疼痛定下了基调

控制第5层神经元活动的主要体感皮层回路的抑制丧失驱动疼痛超敏​​反应。恢复这种抑制作用会重置抑制作用－兴奋平衡，从而产生镇痛作用。