Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

中文翻译：

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单基因免疫疾病和严重的特应性疾病。

严重的过敏性疾病是常见的，并且很少描述特应性的单基因原因。一项新的研究令人信服地将严重的特应性皮炎与具有显性干扰活性的杂合性CARD11突变联系起来，这及时提醒我们，临床医生在照料患有严重过敏性疾病的患者时应考虑潜在的单基因免疫疾病的可能性。