Asymmetric alkylation of remote C(sp3)–H bonds by combining proton-coupled electron transfer with chiral Lewis acid catalysis,Chemical Communications

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Asymmetric alkylation of remote C(sp3)–H bonds by combining proton-coupled electron transfer with chiral Lewis acid catalysis
Chemical Communications ( IF 4.3 ) Pub Date : 2017-07-26 00:00:00 , DOI: 10.1039/c7cc04941b
Wei Yuan _{1,

2,

3,

4} , Zijun Zhou _{1,

2,

3,

4} , Lei Gong _{1,

2,

3,

4} , Eric Meggers _{1,

2,

3,

4,

5}

Affiliation

The catalytic asymmetric alkylation of the remote, unactivated δ-position of N-alkyl amides was enabled by the combination of visible-light-induced proton-coupled electron transfer, 1,5-hydrogen atom transfer, and chiral Lewis acid catalysis in up to 82% yield and up to 97% ee.

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